Assay Detail
Binding
CHEMBL663525
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Cyclin-dependent kinase 2-cyclin E
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 2/cyclin E (CHEMBL2094126) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Synthesis, structure-activity relationship, and biological studies of indolocarbazoles as potent cyclin D1-CDK4 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.64 | 5.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL64742 | — | — | 1 | 5.64 |
| CHEMBL292021 | — | — | 1 | - |
| CHEMBL302854 | — | — | 1 | - |
| CHEMBL61790 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL64742 | — | IC50 | = | 2287.0 | nM | 5.64 |
| CHEMBL292021 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL302854 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL61790 | — | IC50 | > | 2000.0 | nM | - |