Assay Detail
Binding
CHEMBL663528
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Inhibitory activity against Cyclin-dependent kinase 2-cyclin E
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 2/cyclin E (CHEMBL2094126) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
1H-Pyrazolo[3,4-b]pyridine inhibitors of cyclin-dependent kinases: highly potent 2,6-Difluorophenacyl analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 6.64 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL310840 | — | — | 1 | 8.05 |
| CHEMBL309925 | — | — | 1 | 7.70 |
| CHEMBL310567 | — | — | 1 | 7.66 |
| CHEMBL81211 | — | — | 1 | 7.57 |
| CHEMBL79049 | — | — | 1 | 7.44 |
| CHEMBL79452 | — | — | 1 | 7.44 |
| CHEMBL78200 | — | — | 1 | 7.19 |
| CHEMBL14619 | SQ-67563 | — | 1 | 6.96 |
| CHEMBL312657 | — | — | 1 | 6.75 |
| CHEMBL82243 | — | — | 1 | 6.70 |
| CHEMBL78959 | — | — | 1 | 6.68 |
| CHEMBL77843 | — | — | 1 | 6.68 |
| CHEMBL76925 | — | — | 1 | 6.47 |
| CHEMBL76872 | — | — | 1 | 6.28 |
| CHEMBL78427 | — | — | 1 | 6.18 |
| CHEMBL81771 | — | — | 1 | 6.14 |
| CHEMBL311962 | — | — | 1 | 5.62 |
| CHEMBL77726 | — | — | 1 | 5.57 |
| CHEMBL310376 | — | — | 1 | 5.09 |
| CHEMBL78194 | — | — | 1 | 4.72 |
| CHEMBL311952 | — | — | 1 | - |
| CHEMBL78792 | — | — | 1 | - |
| CHEMBL80750 | — | — | 1 | - |
| CHEMBL79937 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL310840 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL309925 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL310567 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL81211 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL79049 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL79452 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL78200 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL14619 | SQ-67563 | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL312657 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL82243 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL78959 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL77843 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL76925 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL76872 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL78427 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL81771 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL311962 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL77726 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL310376 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL78194 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL311952 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL78792 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL80750 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL79937 | — | IC50 | > | 1000.0 | nM | - |