Assay Detail
Binding
CHEMBL663590
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inhibition of [3H]DADLE binding to delta-opioid receptor of mouse brain homogenates
12
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Pyrrolooctahydroisoquinolines as potent and selective opioid receptor ligands: SAR analysis and docking studies
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 8.45 | 9.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL327745 | — | — | 1 | 9.64 |
| CHEMBL2051964 | — | — | 1 | 9.34 |
| CHEMBL100729 | — | — | 3 | 9.02 |
| CHEMBL101516 | — | — | 1 | 8.82 |
| CHEMBL108076 | — | — | 1 | 8.68 |
| CHEMBL322181 | — | — | 1 | 8.62 |
| CHEMBL100911 | — | — | 1 | 8.59 |
| CHEMBL316863 | — | — | 1 | 8.52 |
| CHEMBL101623 | — | — | 1 | 8.17 |
| CHEMBL327956 | — | — | 1 | 7.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL327745 | — | Ki | = | 0.23 | nM | 9.64 |
| CHEMBL2051964 | — | Ki | = | 0.46 | nM | 9.34 |
| CHEMBL100729 | — | Ki | = | 0.95 | nM | 9.02 |
| CHEMBL101516 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL100729 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL108076 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL322181 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL100911 | — | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL316863 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL101623 | — | Ki | = | 6.8 | nM | 8.17 |
| CHEMBL327956 | — | Ki | = | 15.1 | nM | 7.82 |
| CHEMBL100729 | — | Ki | = | 3535.0 | nM | 5.45 |