Assay Detail
Binding
CHEMBL663645
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Inhibition of topoisomerase I activity was determined in vitro by using the cleavable complex assay(calf thymus)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and antitumor activity of novel water soluble derivatives of camptothecin as specific inhibitors of topoisomerase I.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.85 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL338843 | — | — | 1 | 7.96 |
| CHEMBL335455 | — | — | 1 | 7.82 |
| CHEMBL307794 | — | — | 1 | 7.11 |
| CHEMBL128315 | — | — | 1 | 6.52 |
| CHEMBL341028 | — | — | 1 | 6.38 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 6.17 |
| CHEMBL84 | TOPOTECAN | 4.0 | 1 | 5.99 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL338843 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL335455 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL307794 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL128315 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL341028 | — | IC50 | = | 416.0 | nM | 6.38 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 679.0 | nM | 6.17 |
| CHEMBL84 | TOPOTECAN | IC50 | = | 1028.0 | nM | 5.99 |