Assay Detail
Binding
CHEMBL663770
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In vitro inhibition of recombinant Cyclin Dependent Kinase-2/Cyclin E.
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 2/cyclin E (CHEMBL2094126) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
A new series of potent oxindole inhibitors of CDK2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 7.91 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL355631 | — | — | 1 | 8.70 |
| CHEMBL424207 | — | — | 1 | 8.52 |
| CHEMBL354634 | — | — | 1 | 8.52 |
| CHEMBL354995 | — | — | 1 | 8.40 |
| CHEMBL170752 | — | — | 1 | 8.40 |
| CHEMBL172640 | — | — | 1 | 8.40 |
| CHEMBL170130 | — | — | 1 | 8.40 |
| CHEMBL412267 | — | — | 1 | 8.40 |
| CHEMBL171439 | — | — | 1 | 8.30 |
| CHEMBL353182 | — | — | 1 | 8.30 |
| CHEMBL536029 | — | — | 1 | 8.22 |
| CHEMBL171297 | — | — | 1 | 8.15 |
| CHEMBL422738 | — | — | 1 | 8.10 |
| CHEMBL366440 | — | — | 1 | 8.05 |
| CHEMBL352984 | — | — | 1 | 7.75 |
| CHEMBL169591 | — | — | 1 | 7.68 |
| CHEMBL173058 | — | — | 1 | 7.68 |
| CHEMBL354650 | — | — | 1 | 7.58 |
| CHEMBL170870 | — | — | 1 | 7.35 |
| CHEMBL367232 | — | — | 1 | 7.02 |
| CHEMBL368157 | — | — | 1 | 6.07 |
| CHEMBL171747 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL355631 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL424207 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL354634 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL354995 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL170752 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL172640 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL170130 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL412267 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL171439 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL353182 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL536029 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL171297 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL422738 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL366440 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL352984 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL169591 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL173058 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL354650 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL170870 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL367232 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL368157 | — | IC50 | = | 847.0 | nM | 6.07 |
| CHEMBL171747 | — | IC50 | = | 1000.0 | nM | 6.00 |