Assay Detail
Binding
CHEMBL663903
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Inhibitory activity against DNA topoisomerase-1 obtained from Hela cells
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HeLa |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Acylshikonin analogues: synthesis and inhibition of DNA topoisomerase-I.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 4.23 | 4.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL276448 | — | — | 1 | 4.40 |
| CHEMBL8951 | — | — | 1 | 4.36 |
| CHEMBL403516 | ACETYLSHIKONIN | — | 1 | 4.35 |
| CHEMBL267024 | DIMETHYLACRYLSHIKONIN | — | 1 | 4.11 |
| CHEMBL267275 | — | — | 1 | 4.10 |
| CHEMBL9416 | ISOBUTYLSHIKONIN | — | 1 | 4.08 |
| CHEMBL8937 | — | — | 1 | - |
| CHEMBL9148 | — | — | 1 | - |
| CHEMBL8806 | — | — | 1 | - |
| CHEMBL9196 | — | — | 1 | - |
| CHEMBL267435 | — | — | 1 | - |
| CHEMBL9470 | SHIKONIN | — | 1 | - |
| CHEMBL9499 | — | — | 1 | - |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | - |
| CHEMBL269519 | — | — | 1 | - |
| CHEMBL275029 | — | — | 1 | - |
| CHEMBL9469 | — | — | 1 | - |
| CHEMBL265619 | — | — | 1 | - |
| CHEMBL9259 | — | — | 1 | - |
| CHEMBL8805 | — | — | 1 | - |
| CHEMBL9320 | — | — | 1 | - |
| CHEMBL266603 | — | — | 1 | - |
| CHEMBL8834 | — | — | 1 | - |
| CHEMBL9523 | — | — | 1 | - |
| CHEMBL9518 | — | — | 1 | - |
| CHEMBL8794 | — | — | 1 | - |
| CHEMBL9023 | — | — | 1 | - |
| CHEMBL9266 | — | — | 1 | - |
| CHEMBL9164 | — | — | 1 | - |
| CHEMBL9338 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL276448 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL8951 | — | IC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL403516 | ACETYLSHIKONIN | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL267024 | DIMETHYLACRYLSHIKONIN | IC50 | = | 77000.0 | nM | 4.11 |
| CHEMBL267275 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL9416 | ISOBUTYLSHIKONIN | IC50 | = | 84000.0 | nM | 4.08 |
| CHEMBL9196 | — | IC50 | = | 126000.0 | nM | - |
| CHEMBL8940 | — | IC50 | > | 625000.0 | nM | - |
| CHEMBL267435 | — | IC50 | > | 625000.0 | nM | - |
| CHEMBL9470 | SHIKONIN | IC50 | = | 208000.0 | nM | - |
| CHEMBL9499 | — | IC50 | = | 161000.0 | nM | - |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 127000.0 | nM | - |
| CHEMBL269519 | — | IC50 | > | 625000.0 | nM | - |
| CHEMBL275029 | — | IC50 | > | 625000.0 | nM | - |
| CHEMBL9469 | — | IC50 | > | 625000.0 | nM | - |
| CHEMBL265619 | — | IC50 | = | 207000.0 | nM | - |
| CHEMBL9148 | — | IC50 | = | 130000.0 | nM | - |
| CHEMBL267049 | — | IC50 | > | 625000.0 | nM | - |
| CHEMBL8804 | — | IC50 | = | 222000.0 | nM | - |
| CHEMBL266355 | — | IC50 | > | 625000.0 | nM | - |
| CHEMBL8806 | — | IC50 | = | 144000.0 | nM | - |
| CHEMBL8937 | — | IC50 | > | 625000.0 | nM | - |
| CHEMBL9259 | — | IC50 | > | 625000.0 | nM | - |
| CHEMBL8805 | — | IC50 | = | 153000.0 | nM | - |
| CHEMBL9320 | — | IC50 | = | 250000.0 | nM | - |
| CHEMBL266603 | — | IC50 | = | 153000.0 | nM | - |
| CHEMBL8834 | — | IC50 | = | 137000.0 | nM | - |
| CHEMBL9523 | — | IC50 | > | 625000.0 | nM | - |
| CHEMBL9518 | — | IC50 | > | 625000.0 | nM | - |
| CHEMBL8794 | — | IC50 | = | 115000.0 | nM | - |
| CHEMBL9023 | — | IC50 | > | 625000.0 | nM | - |
| CHEMBL9266 | — | IC50 | = | 153000.0 | nM | - |
| CHEMBL9164 | — | IC50 | = | 625000.0 | nM | - |
| CHEMBL9338 | — | IC50 | > | 625000.0 | nM | - |