Assay Detail
Functional
CHEMBL663908
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effective concentration for the agonist in the isolated blood vessel using in vitro saphenous vein
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Canis lupus familiaris |
| Tissue | Saphenous vein |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Design, synthesis, and structure-activity relationships of a new series of alpha-adrenergic agonists: spiro[(1,3-diazacyclopent-1-ene)-5,2'-(1',2',3',4'- tetrahydronaphthalene)].
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 41 | 5.59 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL133231 | — | — | 1 | 7.85 |
| CHEMBL337879 | — | — | 1 | 7.64 |
| CHEMBL340679 | — | — | 1 | 7.57 |
| CHEMBL132119 | — | — | 1 | 7.16 |
| CHEMBL130784 | — | — | 1 | 6.75 |
| CHEMBL128582 | — | — | 1 | 6.62 |
| CHEMBL98471 | — | — | 1 | 6.58 |
| CHEMBL336331 | — | — | 1 | 6.52 |
| CHEMBL131417 | — | — | 1 | 6.30 |
| CHEMBL445329 | — | — | 1 | 6.10 |
| CHEMBL336332 | — | — | 1 | 6.10 |
| CHEMBL130853 | — | — | 1 | 5.89 |
| CHEMBL338683 | — | — | 1 | 5.70 |
| CHEMBL128574 | — | — | 1 | 5.68 |
| CHEMBL131220 | — | — | 1 | 5.64 |
| CHEMBL128593 | — | — | 1 | 5.64 |
| CHEMBL336631 | — | — | 1 | 5.62 |
| CHEMBL336521 | — | — | 1 | 5.57 |
| CHEMBL130589 | — | — | 1 | 5.57 |
| CHEMBL338616 | — | — | 1 | 5.54 |
| CHEMBL335694 | — | — | 1 | 5.41 |
| CHEMBL131539 | — | — | 1 | 5.41 |
| CHEMBL130679 | — | — | 1 | 5.37 |
| CHEMBL101340 | — | — | 1 | 5.29 |
| CHEMBL128055 | — | — | 1 | 5.26 |
| CHEMBL441833 | — | — | 1 | 5.22 |
| CHEMBL131655 | — | — | 1 | 5.20 |
| CHEMBL133579 | — | — | 1 | 5.15 |
| CHEMBL131596 | — | — | 1 | 5.14 |
| CHEMBL336970 | — | — | 1 | 5.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL133231 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL337879 | — | EC50 | = | 23.0 | nM | 7.64 |
| CHEMBL340679 | — | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL132119 | — | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL130784 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL128582 | — | EC50 | = | 240.0 | nM | 6.62 |
| CHEMBL98471 | — | EC50 | = | 260.0 | nM | 6.58 |
| CHEMBL336331 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL131417 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL445329 | — | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL336332 | — | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL130853 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL338683 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL128574 | — | EC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL128593 | — | EC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL131220 | — | EC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL336631 | — | EC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL336521 | — | EC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL130589 | — | EC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL338616 | — | EC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL335694 | — | EC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL131539 | — | EC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL130679 | — | EC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL101340 | — | EC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL128055 | — | EC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL441833 | — | EC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL131655 | — | EC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL133579 | — | EC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL131596 | — | EC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL336970 | — | EC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL131363 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL130044 | — | EC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL414431 | — | EC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL131553 | — | EC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL130570 | — | EC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL128420 | — | EC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL129845 | — | EC50 | = | 52000.0 | nM | 4.28 |
| CHEMBL131240 | — | EC50 | = | 52000.0 | nM | 4.28 |
| CHEMBL130772 | — | EC50 | = | 66000.0 | nM | 4.18 |
| CHEMBL132951 | — | EC50 | = | 75000.0 | nM | 4.12 |
| CHEMBL334757 | — | EC50 | = | 400000.0 | nM | - |