Assay Detail
Binding
CHEMBL663971
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro binding affinity against cysteinyl leukotriene D4 receptor from guinea pig lung membrane
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Lung |
| Subcellular | Membrane |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
The development of a novel series of (quinolin-2-ylmethoxy)phenyl-containing compounds as high-affinity leukotriene receptor antagonists. 3. Structural variation of the acidic side chain to give antagonists of enhanced potency.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 36 | 7.38 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL22033 | ICI-198615 | — | 1 | 9.70 |
| CHEMBL93991 | — | — | 1 | 8.10 |
| CHEMBL317945 | — | — | 1 | 7.96 |
| CHEMBL97656 | — | — | 1 | 7.92 |
| CHEMBL97400 | — | — | 1 | 7.85 |
| CHEMBL328815 | — | — | 1 | 7.82 |
| CHEMBL98232 | — | — | 1 | 7.77 |
| CHEMBL97541 | — | — | 1 | 7.75 |
| CHEMBL264799 | — | — | 1 | 7.70 |
| CHEMBL97713 | — | — | 1 | 7.68 |
| CHEMBL421750 | — | — | 1 | 7.66 |
| CHEMBL97693 | — | — | 1 | 7.62 |
| CHEMBL96592 | — | — | 1 | 7.60 |
| CHEMBL420082 | — | — | 1 | 7.60 |
| CHEMBL97401 | — | — | 1 | 7.51 |
| CHEMBL98517 | — | — | 1 | 7.51 |
| CHEMBL329753 | — | — | 1 | 7.47 |
| CHEMBL418551 | — | — | 1 | 7.38 |
| CHEMBL93877 | — | — | 1 | 7.37 |
| CHEMBL97701 | — | — | 1 | 7.37 |
| CHEMBL95049 | — | — | 1 | 7.37 |
| CHEMBL420819 | — | — | 1 | 7.30 |
| CHEMBL94443 | — | — | 1 | 7.29 |
| CHEMBL94465 | — | — | 1 | 7.28 |
| CHEMBL97287 | — | — | 1 | 7.16 |
| CHEMBL318021 | — | — | 1 | 7.16 |
| CHEMBL97359 | — | — | 1 | 7.07 |
| CHEMBL94945 | — | — | 1 | 7.05 |
| CHEMBL94456 | — | — | 1 | 7.00 |
| CHEMBL94893 | — | — | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL22033 | ICI-198615 | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL93991 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL317945 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL97656 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL97400 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL328815 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL98232 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL97541 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL264799 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL97713 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL421750 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL97693 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL96592 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL420082 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL98517 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL97401 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL329753 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL418551 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL93877 | — | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL95049 | — | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL97701 | — | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL420819 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL94443 | — | Ki | = | 51.0 | nM | 7.29 |
| CHEMBL94465 | — | Ki | = | 52.0 | nM | 7.28 |
| CHEMBL97287 | — | Ki | = | 69.0 | nM | 7.16 |
| CHEMBL318021 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL97359 | — | Ki | = | 85.0 | nM | 7.07 |
| CHEMBL94945 | — | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL94456 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL94893 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL97743 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL18471 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL94949 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL162358 | TOMELUKAST | Ki | = | 800.0 | nM | 6.10 |
| CHEMBL267475 | FPL-55712 | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL277292 | — | Ki | = | 1200.0 | nM | 5.92 |