Assay Detail
Binding
CHEMBL664027
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibitory activity against Dipeptidyl peptidase II (DPP II) obtained form bovine kidney homogenate
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Kidney |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
1-[[(3-hydroxy-1-adamantyl)amino]acetyl]-2-cyano-(S)-pyrrolidine: a potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitor with antihyperglycemic properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.92 | 4.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL77539 | — | — | 1 | 4.92 |
| CHEMBL307636 | — | — | 1 | - |
| CHEMBL3084811 | — | — | 1 | - |
| CHEMBL77538 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL77539 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL307636 | — | IC50 | = | 102000.0 | nM | - |
| CHEMBL3084811 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL77538 | — | IC50 | = | 110000.0 | nM | - |