Assay Detail
Functional
CHEMBL664041
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Concentration required to inhibit nitric oxide synthesis in DLD-1 cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | DLD-1 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Thienopyridines: nitric oxide synthase inhibitors with potent in vivo activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.10 | 5.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL274405 | — | — | 1 | 5.66 |
| CHEMBL8365 | — | — | 1 | 5.44 |
| CHEMBL8292 | — | — | 1 | 5.24 |
| CHEMBL8105 | — | — | 1 | 5.06 |
| CHEMBL8041 | — | — | 1 | 5.04 |
| CHEMBL8281 | — | — | 1 | 4.82 |
| CHEMBL8302 | — | — | 1 | 4.47 |
| CHEMBL256147 | TILARGININE | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL274405 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL8365 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL8292 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL8105 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL8041 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL8281 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL8302 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL256147 | TILARGININE | IC50 | = | 170000.0 | nM | - |