Assay Detail
Functional
CHEMBL664043
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In vitro cytotoxicity against human tumor cell line DLD-1
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | DLD-1 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis and in vitro cytotoxicity of hexacyclic camptothecin analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.83 | 6.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL109188 | — | — | 1 | 6.24 |
| CHEMBL322998 | — | — | 1 | 6.19 |
| CHEMBL109029 | — | — | 1 | 6.07 |
| CHEMBL111658 | — | — | 1 | 5.95 |
| CHEMBL109181 | — | — | 1 | 5.95 |
| CHEMBL441645 | — | — | 1 | 5.74 |
| CHEMBL109521 | — | — | 1 | 5.51 |
| CHEMBL107773 | — | — | 1 | 5.39 |
| CHEMBL109103 | — | — | 1 | 5.39 |
| CHEMBL420670 | — | — | 1 | - |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | - |
| CHEMBL108027 | — | — | 1 | - |
| CHEMBL321011 | — | — | 1 | - |
| CHEMBL108508 | — | — | 1 | - |
| CHEMBL322309 | — | — | 1 | - |
| CHEMBL432606 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL109188 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL322998 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL109029 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL111658 | — | IC50 | = | 1130.0 | nM | 5.95 |
| CHEMBL109181 | — | IC50 | = | 1130.0 | nM | 5.95 |
| CHEMBL441645 | — | IC50 | = | 1810.0 | nM | 5.74 |
| CHEMBL109521 | — | IC50 | = | 3120.0 | nM | 5.51 |
| CHEMBL107773 | — | IC50 | = | 4040.0 | nM | 5.39 |
| CHEMBL109103 | — | IC50 | = | 4040.0 | nM | 5.39 |
| CHEMBL420670 | — | IC50 | = | 8900000.0 | nM | - |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 14000000.0 | nM | - |
| CHEMBL108027 | — | IC50 | = | 610000.0 | nM | - |
| CHEMBL321011 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL108508 | — | IC50 | = | 26000000.0 | nM | - |
| CHEMBL322309 | — | IC50 | = | 7300000.0 | nM | - |
| CHEMBL432606 | — | IC50 | > | 100000.0 | nM | - |