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Assay Detail

CHEMBL664118

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
In vitro inhibition of Bacillus subtilis DNA Polymerase III/azp-12(mutant).
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Bacillus subtilis
Confidence 8 — Homologous single protein target
Curated By Expert

Target

DNA polymerase III PolC-type (CHEMBL3897)
Type SINGLE PROTEIN
Organism Bacillus subtilis (strain 168)

Publication

Inhibitors of Bacillus subtilis DNA polymerase III. 6-Anilinouracils and 6-(alkylamino)uracils.
Wright GE, Brown NC.
J Med Chem (1980) 23 : 34 -38
PubMed 6767030 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 18 4.84 6.07

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL53413 1 6.07
CHEMBL54782 1 5.46
CHEMBL293964 1 5.40
CHEMBL51694 1 4.85
CHEMBL51750 1 4.73
CHEMBL299529 1 4.70
CHEMBL300465 1 4.69
CHEMBL54419 1 4.66
CHEMBL291461 1 4.66
CHEMBL54949 1 4.38
CHEMBL433486 1 4.27
CHEMBL57397 1 4.16
CHEMBL298559 1 -
CHEMBL54362 1 -
CHEMBL52018 1 -
CHEMBL53228 1 -
CHEMBL299172 1 -
CHEMBL54861 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL53413 Ki = 850.0 nM 6.07
CHEMBL54782 Ki = 3500.0 nM 5.46
CHEMBL293964 Ki = 4000.0 nM 5.40
CHEMBL51694 Ki = 14100.0 nM 4.85
CHEMBL51750 Ki = 18600.0 nM 4.73
CHEMBL299529 Ki = 20000.0 nM 4.70
CHEMBL300465 Ki = 20400.0 nM 4.69
CHEMBL54419 Ki = 22000.0 nM 4.66
CHEMBL291461 Ki = 21900.0 nM 4.66
CHEMBL54949 Ki = 41700.0 nM 4.38
CHEMBL433486 Ki = 54000.0 nM 4.27
CHEMBL57397 Ki = 69000.0 nM 4.16
CHEMBL298559 Ki = 1950000.0 nM -
CHEMBL54362 Ki = 2190000.0 nM -
CHEMBL52018 Ki = 178000.0 nM -
CHEMBL53228 Ki = 3800000.0 nM -
CHEMBL299172 Ki = 5130000.0 nM -
CHEMBL54861 Ki = 120000.0 nM -