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Target Snapshot

CHEMBL3897 Target Snapshot

DNA polymerase III PolC-type · SINGLE PROTEIN · Bacillus subtilis (strain 168)

214Compounds
11Assays
0Approved Drugs
159.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P13267. Use UniProt P13267 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P13267 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats DNA polymerase III PolC-type as ChEMBL target CHEMBL3897, mapped to UniProt P13267. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
DNA polymerase III PolC-type
SINGLE PROTEIN · Bacillus subtilis (strain 168)
As of 2026-09-14
ChEMBL target ID
CHEMBL3897
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P13267
DNA polymerase III PolC-type
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether DNA polymerase III PolC-type is the right protein anchor across sources, using UniProt P13267 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelDNA polymerase III PolC-type
UniProt AccessionP13267
Component TypeProtein
Sequence Length1437 aa

DNA polymerase III PolC-type

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as DNA polymerase III PolC-type, mapped to UniProt P13267. Sequence length is 1437 aa.

Mapped IDP13267
Review nameDNA polymerase III PolC-type
OrganismBacillus subtilis (strain 168)
Assay Mix

Activity Type Distribution

KI159.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL381636 8.4 Ki 4.0 Preclinical
CHEMBL381635 8.15 Ki 7.0 Preclinical
CHEMBL373063 8.0 Ki 10.0 Preclinical
CHEMBL202534 7.96 Ki 11.0 Preclinical
CHEMBL205073 7.96 Ki 11.0 Preclinical
CHEMBL203495 7.92 Ki 12.0 Preclinical
CHEMBL555266 7.89 Ki 13.0 Preclinical
CHEMBL381882 7.85 Ki 14.0 Preclinical
CHEMBL202801 7.77 Ki 17.0 Preclinical
CHEMBL202535 7.75 Ki 18.0 Preclinical
Distribution

pChEMBL Value Distribution

4
5.0
3
5.5
10
6.0
26
6.5
59
7.0
24
7.5
3
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

11
Total Assays
146
Tested Compounds
2
Assay Types
Binding — 10 assays, 146 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 10 146 6.9
Functional — 1 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 1 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine