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Compound Detail

CHEMBL381635

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CCc1cc(Nc2cc(=O)n(CCCCN3CCN(c4c(F)cc5c(=O)c(C(=O)O)cn(C6CC6)c5c4F)C[C@H]3C)c(=O)[nH]2)ccc1C

Basic Information

ChEMBL ID CHEMBL381635
Phase Preclinical
Structure Type MOL
InChI Key BSSRCWTVYSAQCP-OAQYLSRUSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
8
Publications
0
Known Names

Molecular Properties

662.7
MW (Da)
4.77
ALogP
9
HBA
3
HBD
132.7
PSA (Ų)
0.20
QED
1
Ro5 Violations
11
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C35H40F2N6O5
MW 662.74
Aromatic Rings 4
Heavy Atoms 48
NP-Likeness -0.94

Activity Summary

Ki 1 meas. best 8.15

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
DNA polymerase III PolC-type
CHEMBL3897
Ki 8.15 8.15 7.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
DNA polymerase III PolC-type Ki = 7.0 nM 8.15 Binding affinity to Bacillus subtilis DNA polymerase3C 16480282

Literature References

PubMed DOI Target Context # Activities
16480282 10.1021/jm0510023 Staphylococcus aureus 3
16480282 10.1021/jm0510023 Enterococcus faecium 2
16480282 10.1021/jm0510023 Unchecked 2
16480282 10.1021/jm0510023 DNA polymerase III PolC-type 1
16480282 10.1021/jm0510023 Bacillus subtilis 1
16480282 10.1021/jm0510023 Enterococcus faecalis 1
16480282 10.1021/jm0510023 Escherichia coli 1
16480282 10.1021/jm0510023 Mus musculus 1

Data from ChEMBL 36 via Core Engine