Assay Detail
Binding
CHEMBL861887
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Binding affinity to Bacillus subtilis DNA polymerase3C
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bacillus subtilis |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
DNA polymerase III PolC-type (CHEMBL3897) ↗| Type | SINGLE PROTEIN |
| Organism | Bacillus subtilis (strain 168) |
Publication
Hybrid antibacterials. DNA polymerase-topoisomerase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 27 | 7.58 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL381636 | — | — | 1 | 8.40 |
| CHEMBL381635 | — | — | 1 | 8.15 |
| CHEMBL373063 | — | — | 1 | 8.00 |
| CHEMBL202534 | — | — | 1 | 7.96 |
| CHEMBL205073 | — | — | 1 | 7.96 |
| CHEMBL203495 | — | — | 1 | 7.92 |
| CHEMBL555266 | — | — | 1 | 7.89 |
| CHEMBL381882 | — | — | 1 | 7.85 |
| CHEMBL202801 | — | — | 1 | 7.77 |
| CHEMBL383544 | — | — | 1 | 7.75 |
| CHEMBL202535 | — | — | 1 | 7.75 |
| CHEMBL377087 | — | — | 1 | 7.72 |
| CHEMBL201900 | — | — | 1 | 7.72 |
| CHEMBL204382 | — | — | 1 | 7.68 |
| CHEMBL379899 | — | — | 1 | 7.62 |
| CHEMBL382019 | — | — | 1 | 7.62 |
| CHEMBL204187 | — | — | 1 | 7.58 |
| CHEMBL204074 | — | — | 1 | 7.48 |
| CHEMBL379011 | — | — | 1 | 7.43 |
| CHEMBL203701 | — | — | 1 | 7.39 |
| CHEMBL327687 | — | — | 1 | 7.18 |
| CHEMBL204016 | — | — | 1 | 7.02 |
| CHEMBL370868 | — | — | 1 | 4.54 |
| CHEMBL9 | NORFLOXACIN | 4.0 | 1 | - |
| CHEMBL8 | CIPROFLOXACIN | 4.0 | 1 | - |
| CHEMBL850 | SPARFLOXACIN | 4.0 | 1 | - |
| CHEMBL126 | LINEZOLID | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL381636 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL381635 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL373063 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL202534 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL205073 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL203495 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL555266 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL381882 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL202801 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL383544 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL202535 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL377087 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL201900 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL204382 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL379899 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL382019 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL204187 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL204074 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL379011 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL203701 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL327687 | — | Ki | = | 66.0 | nM | 7.18 |
| CHEMBL204016 | — | Ki | = | 95.0 | nM | 7.02 |
| CHEMBL370868 | — | Ki | = | 29000.0 | nM | 4.54 |
| CHEMBL9 | NORFLOXACIN | Ki | - | — | - | |
| CHEMBL8 | CIPROFLOXACIN | Ki | - | — | - | |
| CHEMBL850 | SPARFLOXACIN | Ki | - | — | - | |
| CHEMBL126 | LINEZOLID | Ki | - | — | - |