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Assay Detail

CHEMBL664122

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
In vitro test for inhibitory activity against human dipeptidyl peptidase IV.
27
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Dipeptidyl peptidase 4 (CHEMBL284)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

2-cyanopyrrolidides as potent, stable inhibitors of dipeptidyl peptidase IV
Ashworth DM, Atrash B, Baker GR, Baxter AJ, Jenkins PD, Jones D, Szelke M
Bioorg Med Chem Lett (1996) 6 : 1163 -1166
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 27 6.66 8.96

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL16834 1 8.96
CHEMBL307636 1 8.85
CHEMBL63860 1 8.70
CHEMBL3350819 1 8.66
CHEMBL63895 1 8.52
CHEMBL363250 1 8.42
CHEMBL461912 1 8.28
CHEMBL381626 1 7.66
CHEMBL278393 1 7.19
CHEMBL276056 1 6.68
CHEMBL503274 2 6.39
CHEMBL383705 1 6.33
CHEMBL3350816 1 6.28
CHEMBL3350814 1 6.06
CHEMBL3350818 1 6.05
CHEMBL3350817 1 6.04
CHEMBL442952 1 5.92
CHEMBL455542 1 5.70
CHEMBL403882 1 5.68
CHEMBL98008 1 5.67
CHEMBL3350820 1 5.57
CHEMBL459438 1 5.31
CHEMBL3350821 1 5.28
CHEMBL3350815 1 5.22
CHEMBL443622 1 5.16
CHEMBL499101 1 4.84

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL16834 Ki = 1.1 nM 8.96
CHEMBL307636 Ki = 1.4 nM 8.85
CHEMBL63860 Ki = 2.0 nM 8.70
CHEMBL3350819 Ki = 2.2 nM 8.66
CHEMBL63895 Ki = 3.0 nM 8.52
CHEMBL363250 Ki = 3.8 nM 8.42
CHEMBL461912 Ki = 5.2 nM 8.28
CHEMBL381626 Ki = 22.0 nM 7.66
CHEMBL278393 Ki = 64.0 nM 7.19
CHEMBL276056 Ki = 210.0 nM 6.68
CHEMBL503274 Ki = 410.0 nM 6.39
CHEMBL503274 Ki = 440.0 nM 6.36
CHEMBL383705 Ki = 470.0 nM 6.33
CHEMBL3350816 Ki = 520.0 nM 6.28
CHEMBL3350814 Ki = 880.0 nM 6.06
CHEMBL3350818 Ki = 900.0 nM 6.05
CHEMBL3350817 Ki = 910.0 nM 6.04
CHEMBL442952 Ki = 1200.0 nM 5.92
CHEMBL455542 Ki = 2000.0 nM 5.70
CHEMBL403882 Ki = 2100.0 nM 5.68
CHEMBL98008 Ki = 2150.0 nM 5.67
CHEMBL3350820 Ki = 2700.0 nM 5.57
CHEMBL459438 Ki = 4900.0 nM 5.31
CHEMBL3350821 Ki = 5300.0 nM 5.28
CHEMBL3350815 Ki = 6000.0 nM 5.22
CHEMBL443622 Ki = 7000.0 nM 5.16
CHEMBL499101 Ki = 14500.0 nM 4.84