Assay Detail
Functional
CHEMBL664124
Review assay metadata, readout intent, target linkage, and publication context from the same page.
inhibition of tumor colony formation in soft agar
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cercopithecidae |
| Cell Type | COS-1 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Identification of pharmacokinetically stable 3, 10-dibromo-8-chlorobenzocycloheptapyridine farnesyl protein transferase inhibitors with potent enzyme and cellular activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.84 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL423680 | — | — | 1 | 7.30 |
| CHEMBL92499 | — | — | 1 | 7.16 |
| CHEMBL88432 | — | — | 1 | 7.12 |
| CHEMBL298734 | LONAFARNIB | 4.0 | 1 | 7.12 |
| CHEMBL89304 | — | — | 1 | 7.07 |
| CHEMBL328713 | — | — | 1 | 7.00 |
| CHEMBL88713 | — | — | 1 | 7.00 |
| CHEMBL313635 | — | — | 1 | 7.00 |
| CHEMBL443022 | — | — | 1 | 6.96 |
| CHEMBL90050 | — | — | 1 | 6.92 |
| CHEMBL90234 | — | — | 1 | 6.70 |
| CHEMBL264305 | — | — | 1 | 6.70 |
| CHEMBL90962 | — | — | 1 | 6.52 |
| CHEMBL432573 | — | — | 1 | 6.51 |
| CHEMBL327204 | — | — | 1 | 6.48 |
| CHEMBL91213 | — | — | 1 | 6.34 |
| CHEMBL315915 | — | — | 1 | 6.30 |
| CHEMBL90435 | — | — | 1 | - |
| CHEMBL315402 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL423680 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL92499 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL88432 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL298734 | LONAFARNIB | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL89304 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL328713 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL88713 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL313635 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL443022 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL90050 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL90234 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL264305 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL90962 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL432573 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL327204 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL91213 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL315915 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL90435 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL315402 | — | IC50 | > | 500.0 | nM | - |