Assay Detail
Binding
CHEMBL664148
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Noncompetitive Inhibitory activity against rat striatal synaptosomal DHPR enzyme
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and dihydropteridine reductase inhibitory effects of potential metabolites of the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 5.11 | 5.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL109090 | — | — | 1 | 5.72 |
| CHEMBL323998 | — | — | 1 | 5.48 |
| CHEMBL321432 | — | — | 1 | 4.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL109090 | — | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL323998 | — | Ki | = | 3300.0 | nM | 5.48 |
| CHEMBL321432 | — | Ki | = | 74000.0 | nM | 4.13 |