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Assay Detail

CHEMBL664150

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cell growth inhibition against DLD-1 human colon cancer cells using MTS assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type DLD-1
Confidence 1 — Organism
Curated By Expert

Target

DLD-1 (CHEMBL614285)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis and structure-activity relationship of 2-aminobenzophenone derivatives as antimitotic agents.
Liou JP, Chang CW, Song JS, Yang YN, Yeh CF, Tseng HY, Lo YK, Chang YL, Chang CM, Hsieh HP.
J Med Chem (2002) 45 : 2556 -2562
PubMed 12036364 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 6.39 8.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL9011 1 8.30
CHEMBL67 COMBRETASTATIN A4 -1.0 1 7.44
CHEMBL276625 PHENSTATIN 1 7.08
CHEMBL9309 1 7.03
CHEMBL86016 1 6.35
CHEMBL431388 1 6.35
CHEMBL85014 1 6.30
CHEMBL315222 1 6.29
CHEMBL86236 1 6.07
CHEMBL82914 1 5.88
CHEMBL87464 1 5.34
CHEMBL87016 1 5.32
CHEMBL82915 1 5.29
CHEMBL83586 1 -
CHEMBL87695 1 -
CHEMBL85642 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL9011 IC50 = 5.0 nM 8.30
CHEMBL67 COMBRETASTATIN A4 IC50 = 36.0 nM 7.44
CHEMBL276625 PHENSTATIN IC50 = 83.0 nM 7.08
CHEMBL9309 IC50 = 94.0 nM 7.03
CHEMBL86016 IC50 = 451.0 nM 6.35
CHEMBL431388 IC50 = 449.0 nM 6.35
CHEMBL85014 IC50 = 503.0 nM 6.30
CHEMBL315222 IC50 = 511.0 nM 6.29
CHEMBL86236 IC50 = 856.0 nM 6.07
CHEMBL82914 IC50 = 1324.0 nM 5.88
CHEMBL87464 IC50 = 4544.0 nM 5.34
CHEMBL87016 IC50 = 4801.0 nM 5.32
CHEMBL82915 IC50 = 5174.0 nM 5.29
CHEMBL83586 IC50 > 10000.0 nM -
CHEMBL87695 IC50 > 10000.0 nM -
CHEMBL85642 IC50 > 10000.0 nM -