Assay Detail
Functional
CHEMBL664156
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro cytotoxicity against DLD-1 human tumor cell lines.
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | DLD-1 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis and in vitro cytotoxicity of (RS)-20-desethyl-20-substituted camptothecin analogues
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 5.25 | 6.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 6.68 |
| CHEMBL169169 | — | — | 1 | 5.97 |
| CHEMBL166173 | — | — | 1 | 5.92 |
| CHEMBL354031 | — | — | 1 | 5.91 |
| CHEMBL301311 | — | — | 1 | 5.73 |
| CHEMBL355355 | — | — | 1 | 5.62 |
| CHEMBL432949 | — | — | 1 | 5.60 |
| CHEMBL167656 | — | — | 1 | 5.37 |
| CHEMBL354150 | — | — | 1 | 5.15 |
| CHEMBL168888 | — | — | 1 | 4.96 |
| CHEMBL166487 | — | — | 1 | 4.82 |
| CHEMBL355004 | — | — | 1 | 4.77 |
| CHEMBL355556 | — | — | 1 | 4.75 |
| CHEMBL167864 | — | — | 1 | 4.63 |
| CHEMBL353585 | — | — | 1 | 4.59 |
| CHEMBL352630 | — | — | 1 | 4.50 |
| CHEMBL352383 | — | — | 1 | 4.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL169169 | — | IC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL166173 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL354031 | — | IC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL301311 | — | IC50 | = | 1860.0 | nM | 5.73 |
| CHEMBL355355 | — | IC50 | = | 2410.0 | nM | 5.62 |
| CHEMBL432949 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL167656 | — | IC50 | = | 4240.0 | nM | 5.37 |
| CHEMBL354150 | — | IC50 | = | 7040.0 | nM | 5.15 |
| CHEMBL168888 | — | IC50 | = | 10950.0 | nM | 4.96 |
| CHEMBL166487 | — | IC50 | = | 15120.0 | nM | 4.82 |
| CHEMBL355004 | — | IC50 | = | 17090.0 | nM | 4.77 |
| CHEMBL355556 | — | IC50 | = | 17810.0 | nM | 4.75 |
| CHEMBL167864 | — | IC50 | = | 23420.0 | nM | 4.63 |
| CHEMBL353585 | — | IC50 | = | 25820.0 | nM | 4.59 |
| CHEMBL352630 | — | IC50 | = | 31800.0 | nM | 4.50 |
| CHEMBL352383 | — | IC50 | = | 47140.0 | nM | 4.33 |