Assay Detail
Functional
CHEMBL664168
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of cyclooxygenase-1 via inhibition of TXB2 generation in the presence of 1 uM arachidonic acid in human platelet
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Structure-based design of cyclooxygenase-2 selectivity into ketoprofen.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.92 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL571 | KETOPROFEN | 4.0 | 1 | 8.70 |
| CHEMBL150130 | — | — | 1 | 7.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL571 | KETOPROFEN | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL150130 | — | IC50 | = | 74.0 | nM | 7.13 |