Assay Detail
Binding
CHEMBL664192
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Binding affinity was determined against corticotropin releasing factor receptor 1
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Corticotropin-releasing factor receptor 1 (CHEMBL4649) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Corticotropin-releasing hormone receptor antagonists: framework design and synthesis guided by ligand conformational studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 33 | 7.14 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL167241 | — | — | 1 | 9.00 |
| CHEMBL46479 | — | — | 1 | 8.30 |
| CHEMBL432496 | — | — | 1 | 7.66 |
| CHEMBL46798 | — | — | 1 | 7.55 |
| CHEMBL169838 | — | — | 1 | 7.54 |
| CHEMBL353916 | — | — | 1 | 7.47 |
| CHEMBL169359 | — | — | 1 | 7.44 |
| CHEMBL166162 | — | — | 1 | 7.42 |
| CHEMBL43216 | — | — | 1 | 7.37 |
| CHEMBL167264 | — | — | 1 | 7.34 |
| CHEMBL169784 | — | — | 1 | 7.33 |
| CHEMBL355624 | — | — | 1 | 7.32 |
| CHEMBL353774 | — | — | 1 | 7.17 |
| CHEMBL355882 | — | — | 1 | 7.10 |
| CHEMBL168568 | — | — | 1 | 7.02 |
| CHEMBL166760 | — | — | 1 | 6.95 |
| CHEMBL170487 | — | — | 1 | 6.65 |
| CHEMBL168590 | — | — | 1 | 6.44 |
| CHEMBL166946 | — | — | 1 | 6.35 |
| CHEMBL166732 | — | — | 1 | 6.14 |
| CHEMBL354092 | — | — | 1 | 5.89 |
| CHEMBL415752 | — | — | 1 | 5.61 |
| CHEMBL166945 | — | — | 1 | - |
| CHEMBL169004 | — | — | 1 | - |
| CHEMBL355136 | — | — | 1 | - |
| CHEMBL355135 | — | — | 1 | - |
| CHEMBL168591 | — | — | 1 | - |
| CHEMBL165818 | — | — | 1 | - |
| CHEMBL168784 | — | — | 1 | - |
| CHEMBL355218 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL167241 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL46479 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL432496 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL46798 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL169838 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL353916 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL169359 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL166162 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL43216 | — | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL167264 | — | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL169784 | — | Ki | = | 47.0 | nM | 7.33 |
| CHEMBL355624 | — | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL353774 | — | Ki | = | 67.0 | nM | 7.17 |
| CHEMBL355882 | — | Ki | = | 79.0 | nM | 7.10 |
| CHEMBL168568 | — | Ki | = | 96.0 | nM | 7.02 |
| CHEMBL166760 | — | Ki | = | 112.0 | nM | 6.95 |
| CHEMBL170487 | — | Ki | = | 222.0 | nM | 6.65 |
| CHEMBL168590 | — | Ki | = | 363.0 | nM | 6.44 |
| CHEMBL166946 | — | Ki | = | 446.0 | nM | 6.35 |
| CHEMBL166732 | — | Ki | = | 722.0 | nM | 6.14 |
| CHEMBL354092 | — | Ki | = | 1277.0 | nM | 5.89 |
| CHEMBL415752 | — | Ki | = | 2462.0 | nM | 5.61 |
| CHEMBL166945 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL169004 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL355136 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL355135 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL168591 | — | Ki | - | — | - | |
| CHEMBL165818 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL168784 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL355218 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL170055 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL169507 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL355289 | — | Ki | > | 1000.0 | nM | - |