Assay Detail
Binding
CHEMBL664322
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Inhibition of cytochrome P450 CYP2C19
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Pyrazole and isoxazole derivatives as new, potent, and selective 20-hydroxy-5,8,11,14-eicosatetraenoic acid synthase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 5.74 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL112532 | — | — | 1 | 8.15 |
| CHEMBL345544 | — | — | 1 | 7.17 |
| CHEMBL348263 | — | — | 1 | 6.57 |
| CHEMBL267865 | — | — | 1 | 6.57 |
| CHEMBL150278 | — | — | 1 | 6.50 |
| CHEMBL151207 | — | — | 1 | 6.44 |
| CHEMBL151038 | — | — | 1 | 6.32 |
| CHEMBL358214 | — | — | 1 | 6.11 |
| CHEMBL151449 | — | — | 1 | 5.79 |
| CHEMBL151037 | — | — | 1 | 5.71 |
| CHEMBL434317 | — | — | 1 | 5.51 |
| CHEMBL149750 | — | — | 1 | 5.50 |
| CHEMBL150653 | — | — | 1 | 5.45 |
| CHEMBL433737 | — | — | 1 | 5.43 |
| CHEMBL150681 | — | — | 1 | 5.26 |
| CHEMBL359116 | — | — | 1 | 5.22 |
| CHEMBL422858 | — | — | 1 | 5.22 |
| CHEMBL150146 | — | — | 1 | 5.11 |
| CHEMBL151646 | — | — | 1 | 5.07 |
| CHEMBL150799 | — | — | 1 | 4.85 |
| CHEMBL356594 | — | — | 1 | 4.80 |
| CHEMBL150999 | — | — | 1 | 4.73 |
| CHEMBL347303 | — | — | 1 | 4.63 |
| CHEMBL358216 | — | — | 1 | - |
| CHEMBL151974 | — | — | 1 | - |
| CHEMBL151354 | — | — | 1 | - |
| CHEMBL358880 | — | — | 1 | - |
| CHEMBL151280 | — | — | 1 | - |
| CHEMBL151170 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL112532 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL345544 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL348263 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL267865 | — | IC50 | = | 272.0 | nM | 6.57 |
| CHEMBL150278 | — | IC50 | = | 316.0 | nM | 6.50 |
| CHEMBL151207 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL151038 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL358214 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL151449 | — | IC50 | = | 1630.0 | nM | 5.79 |
| CHEMBL151037 | — | IC50 | = | 1970.0 | nM | 5.71 |
| CHEMBL434317 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL149750 | — | IC50 | = | 3160.0 | nM | 5.50 |
| CHEMBL150653 | — | IC50 | = | 3570.0 | nM | 5.45 |
| CHEMBL433737 | — | IC50 | = | 3680.0 | nM | 5.43 |
| CHEMBL150681 | — | IC50 | = | 5510.0 | nM | 5.26 |
| CHEMBL359116 | — | IC50 | = | 6080.0 | nM | 5.22 |
| CHEMBL422858 | — | IC50 | = | 6070.0 | nM | 5.22 |
| CHEMBL150146 | — | IC50 | = | 7860.0 | nM | 5.11 |
| CHEMBL151646 | — | IC50 | = | 8440.0 | nM | 5.07 |
| CHEMBL150799 | — | IC50 | = | 14200.0 | nM | 4.85 |
| CHEMBL356594 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL150999 | — | IC50 | = | 18700.0 | nM | 4.73 |
| CHEMBL347303 | — | IC50 | = | 23500.0 | nM | 4.63 |
| CHEMBL358216 | — | IC50 | < | 46.0 | nM | - |
| CHEMBL151974 | — | IC50 | > | 46.0 | nM | - |
| CHEMBL151354 | — | IC50 | < | 46.0 | nM | - |
| CHEMBL358880 | — | IC50 | < | 46.0 | nM | - |
| CHEMBL151280 | — | IC50 | < | 46.0 | nM | - |
| CHEMBL151170 | — | IC50 | > | 46.0 | nM | - |