Assay Detail
Binding
CHEMBL664331
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In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome
68
Total Activities
68
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Estrogen synthetase inhibitors. 2. Comparison of the in vitro aromatase inhibitory activity for a variety of nitrogen heterocycles substituted with diarylmethane or diarylmethanol groups.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 68 | 7.20 | 8.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL135381 | — | — | 1 | 8.19 |
| CHEMBL135063 | — | — | 1 | 8.08 |
| CHEMBL341386 | — | — | 1 | 8.06 |
| CHEMBL436369 | — | — | 1 | 8.05 |
| CHEMBL137604 | — | — | 1 | 8.03 |
| CHEMBL135563 | — | — | 1 | 8.03 |
| CHEMBL137552 | — | — | 1 | 8.02 |
| CHEMBL335050 | — | — | 1 | 7.98 |
| CHEMBL135595 | — | — | 1 | 7.97 |
| CHEMBL137001 | — | — | 1 | 7.96 |
| CHEMBL135172 | — | — | 1 | 7.95 |
| CHEMBL135494 | — | — | 1 | 7.90 |
| CHEMBL344904 | — | — | 1 | 7.80 |
| CHEMBL133262 | — | — | 1 | 7.77 |
| CHEMBL135378 | — | — | 1 | 7.75 |
| CHEMBL132929 | — | — | 1 | 7.73 |
| CHEMBL132708 | — | — | 1 | 7.72 |
| CHEMBL343072 | — | — | 1 | 7.70 |
| CHEMBL342180 | — | — | 1 | 7.58 |
| CHEMBL135921 | — | — | 1 | 7.55 |
| CHEMBL133198 | — | — | 1 | 7.54 |
| CHEMBL137589 | — | — | 1 | 7.52 |
| CHEMBL137373 | — | — | 1 | 7.40 |
| CHEMBL135606 | — | — | 1 | 7.40 |
| CHEMBL335215 | — | — | 1 | 7.38 |
| CHEMBL137396 | — | — | 1 | 7.30 |
| CHEMBL137049 | — | — | 1 | 7.30 |
| CHEMBL29669 | — | — | 1 | 7.26 |
| CHEMBL137584 | — | — | 1 | 7.24 |
| CHEMBL336708 | — | — | 1 | 7.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL135381 | — | EC50 | = | 6.4 | nM | 8.19 |
| CHEMBL135063 | — | EC50 | = | 8.4 | nM | 8.08 |
| CHEMBL341386 | — | EC50 | = | 8.8 | nM | 8.06 |
| CHEMBL436369 | — | EC50 | = | 8.9 | nM | 8.05 |
| CHEMBL137604 | — | EC50 | = | 9.4 | nM | 8.03 |
| CHEMBL135563 | — | EC50 | = | 9.3 | nM | 8.03 |
| CHEMBL137552 | — | EC50 | = | 9.6 | nM | 8.02 |
| CHEMBL335050 | — | EC50 | = | 10.5 | nM | 7.98 |
| CHEMBL135595 | — | EC50 | = | 10.8 | nM | 7.97 |
| CHEMBL137001 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL135172 | — | EC50 | = | 11.3 | nM | 7.95 |
| CHEMBL135494 | — | EC50 | = | 12.5 | nM | 7.90 |
| CHEMBL344904 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL133262 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL135378 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL132929 | — | EC50 | = | 18.5 | nM | 7.73 |
| CHEMBL132708 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL343072 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL342180 | — | EC50 | = | 26.0 | nM | 7.58 |
| CHEMBL135921 | — | EC50 | = | 28.0 | nM | 7.55 |
| CHEMBL133198 | — | EC50 | = | 28.5 | nM | 7.54 |
| CHEMBL137589 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL137373 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL135606 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL335215 | — | EC50 | = | 42.0 | nM | 7.38 |
| CHEMBL137396 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL137049 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL29669 | — | EC50 | = | 55.0 | nM | 7.26 |
| CHEMBL137584 | — | EC50 | = | 57.0 | nM | 7.24 |
| CHEMBL336708 | — | EC50 | = | 61.0 | nM | 7.21 |
| CHEMBL137002 | — | EC50 | = | 66.0 | nM | 7.18 |
| CHEMBL29904 | — | EC50 | = | 71.0 | nM | 7.15 |
| CHEMBL133145 | — | EC50 | = | 76.0 | nM | 7.12 |
| CHEMBL335836 | — | EC50 | = | 84.0 | nM | 7.08 |
| CHEMBL415725 | — | EC50 | = | 84.0 | nM | 7.08 |
| CHEMBL334999 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL336616 | — | EC50 | = | 94.0 | nM | 7.03 |
| CHEMBL336638 | — | EC50 | = | 125.0 | nM | 6.90 |
| CHEMBL133026 | — | EC50 | = | 145.0 | nM | 6.84 |
| CHEMBL135340 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL135115 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL554619 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL133079 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL334958 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL138538 | — | EC50 | = | 230.0 | nM | 6.64 |
| CHEMBL135709 | — | EC50 | = | 315.0 | nM | 6.50 |
| CHEMBL135633 | — | EC50 | = | 322.0 | nM | 6.49 |
| CHEMBL337750 | — | EC50 | = | 650.0 | nM | 6.19 |
| CHEMBL135540 | — | EC50 | = | 670.0 | nM | 6.17 |
| CHEMBL133082 | — | EC50 | = | 1600.0 | nM | 5.80 |