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Assay Detail

CHEMBL664363

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Tested for the inhibition of lipid peroxidation in bovine brain phospholipid liposomes
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Arachidonate 5-lipoxygenase (CHEMBL2980)
Type SINGLE PROTEIN
Organism Bos taurus

Publication

Antipsoriatic anthrones with modulated redox properties. 1. Novel 10-substituted 1,8-dihydroxy-9(10H)-anthracenones as inhibitors of 5-lipoxygenase.
Müller K, Gürster D, Piwek S, Wiegrebe W.
J Med Chem (1993) 36 : 4099 -4107
PubMed 8258834 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 5.53 6.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL334941 1 6.00
CHEMBL52 NORDIHYDROGUAIARETIC ACID 1 6.00
CHEMBL134069 1 5.70
CHEMBL130382 1 5.70
CHEMBL335405 1 5.70
CHEMBL130302 1 5.70
CHEMBL132990 1 5.70
CHEMBL130560 1 5.70
CHEMBL133058 1 5.70
CHEMBL130209 1 5.70
CHEMBL133805 1 5.70
CHEMBL339100 1 5.40
CHEMBL130968 BUTANTRONE 2.0 1 5.40
CHEMBL131667 1 5.10
CHEMBL338715 1 5.10
CHEMBL46469 ANTHRALIN 2.0 1 4.92
CHEMBL337845 1 4.85
CHEMBL36648 LONAPALENE 2.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL334941 IC50 = 1000.0 nM 6.00
CHEMBL52 NORDIHYDROGUAIARETIC ACID IC50 = 1000.0 nM 6.00
CHEMBL134069 IC50 = 2000.0 nM 5.70
CHEMBL130382 IC50 = 2000.0 nM 5.70
CHEMBL335405 IC50 = 2000.0 nM 5.70
CHEMBL130302 IC50 = 2000.0 nM 5.70
CHEMBL132990 IC50 = 2000.0 nM 5.70
CHEMBL130560 IC50 = 2000.0 nM 5.70
CHEMBL133058 IC50 = 2000.0 nM 5.70
CHEMBL130209 IC50 = 2000.0 nM 5.70
CHEMBL133805 IC50 = 2000.0 nM 5.70
CHEMBL339100 IC50 = 4000.0 nM 5.40
CHEMBL130968 BUTANTRONE IC50 = 4000.0 nM 5.40
CHEMBL131667 IC50 = 8000.0 nM 5.10
CHEMBL338715 IC50 = 8000.0 nM 5.10
CHEMBL46469 ANTHRALIN IC50 = 12000.0 nM 4.92
CHEMBL337845 IC50 = 14000.0 nM 4.85
CHEMBL36648 LONAPALENE IC50 > 50000.0 nM -