Assay Detail
Binding
CHEMBL664430
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Inhibition of dihydrofolate reductase from Pneumocystis carinii.
18
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Quantitative structure-activity relationships of the inhibition of Pneumocystis carinii dihydrofolate reductase by 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(X-phenyl)-s-triazines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 18 | 6.91 | 8.99 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL33697 | — | — | 1 | 8.99 |
| CHEMBL20587 | — | — | 1 | 8.62 |
| CHEMBL20224 | — | — | 1 | 8.42 |
| CHEMBL282044 | — | — | 1 | 8.11 |
| CHEMBL21254 | — | — | 1 | 7.90 |
| CHEMBL7130 | — | — | 1 | 7.65 |
| CHEMBL20393 | — | — | 1 | 7.35 |
| CHEMBL21258 | — | — | 1 | 7.34 |
| CHEMBL20874 | — | — | 1 | 7.22 |
| CHEMBL6948 | — | — | 1 | 7.11 |
| CHEMBL268914 | — | — | 1 | 6.93 |
| CHEMBL6742 | — | — | 1 | 6.51 |
| CHEMBL266319 | — | — | 1 | 6.46 |
| CHEMBL20911 | — | — | 2 | 6.03 |
| CHEMBL278587 | — | — | 1 | 5.83 |
| CHEMBL284553 | — | — | 1 | 4.70 |
| CHEMBL266734 | — | — | 1 | 4.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL33697 | — | Ki | = | 1.023 | nM | 8.99 |
| CHEMBL20587 | — | Ki | = | 2.399 | nM | 8.62 |
| CHEMBL20224 | — | Ki | = | 3.802 | nM | 8.42 |
| CHEMBL282044 | — | Ki | = | 7.762 | nM | 8.11 |
| CHEMBL21254 | — | Ki | = | 12.59 | nM | 7.90 |
| CHEMBL7130 | — | Ki | = | 22.39 | nM | 7.65 |
| CHEMBL20393 | — | Ki | = | 44.67 | nM | 7.35 |
| CHEMBL21258 | — | Ki | = | 45.71 | nM | 7.34 |
| CHEMBL20874 | — | Ki | = | 60.26 | nM | 7.22 |
| CHEMBL6948 | — | Ki | = | 77.62 | nM | 7.11 |
| CHEMBL268914 | — | Ki | = | 117.49 | nM | 6.93 |
| CHEMBL6742 | — | Ki | = | 309.03 | nM | 6.51 |
| CHEMBL266319 | — | Ki | = | 346.74 | nM | 6.46 |
| CHEMBL20911 | — | Ki | = | 933.25 | nM | 6.03 |
| CHEMBL278587 | — | Ki | = | 1479.11 | nM | 5.83 |
| CHEMBL20911 | — | Ki | = | 7244.36 | nM | 5.14 |
| CHEMBL284553 | — | Ki | = | 19952.62 | nM | 4.70 |
| CHEMBL266734 | — | Ki | = | 70794.58 | nM | 4.15 |