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Assay Detail

CHEMBL664447

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory activity against binding of para-aminobenzoic acid to synthase
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Escherichia coli
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Dihydropteroate synthase (CHEMBL4032)
Type SINGLE PROTEIN
Organism Escherichia coli K-12

Publication

Monocyclic pteridine analogues. Inhibition of Escherichia coli dihydropteroate synthase by 6-amino-5-nitrosoisocytosines.
Lever OW, Bell LN, McGuire HM, Ferone R.
J Med Chem (1985) 28 : 1870 -1874
PubMed 3906132 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 5.85 5.85

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL442357 1 5.85

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL442357 IC50 = 1400.0 nM 5.85