Assay Detail
Binding
CHEMBL664525
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against Dipeptidyl peptidase IV (DPP IV) obtained from rat plasma
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Plasma |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
1-[[(3-hydroxy-1-adamantyl)amino]acetyl]-2-cyano-(S)-pyrrolidine: a potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitor with antihyperglycemic properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.99 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL77538 | — | — | 1 | 8.22 |
| CHEMBL77539 | — | — | 1 | 7.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL77538 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL77539 | — | IC50 | = | 17.3 | nM | 7.76 |