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Assay Detail

CHEMBL664612

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Ability to inhibit growth of Dictostelium discoideum.
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Dictyostelium discoideum
Confidence 1 — Organism
Curated By Expert

Target

Dictyostelium discoideum (CHEMBL612373)
Type ORGANISM
Organism Dictyostelium discoideum

Publication

An investigation of bone resorption and Dictyostelium discoideum growth inhibition by bisphosphonate drugs.
Szabo CM, Martin MB, Oldfield E.
J Med Chem (2002) 45 : 2894 -2903
PubMed 12086477 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 4.67 5.05

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL55140 1 5.05
CHEMBL291736 1 4.92
CHEMBL923 RISEDRONIC ACID 4.0 1 4.89
CHEMBL330617 1 4.89
CHEMBL294192 1 4.82
CHEMBL99369 PIRIDRONIC ACID 2.0 1 4.70
CHEMBL870 ALENDRONIC ACID 4.0 1 4.50
CHEMBL317573 1 4.44
CHEMBL98810 1 4.42
CHEMBL98719 1 4.40
CHEMBL100041 1 4.36
CHEMBL317313 1 -
CHEMBL834 PAMIDRONIC ACID 4.0 1 -
CHEMBL871 ETIDRONIC ACID 4.0 1 -
CHEMBL293522 1 -
CHEMBL327763 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL55140 IC50 = 9000.0 nM 5.05
CHEMBL291736 IC50 = 12000.0 nM 4.92
CHEMBL923 RISEDRONIC ACID IC50 = 13000.0 nM 4.89
CHEMBL330617 IC50 = 13000.0 nM 4.89
CHEMBL294192 IC50 = 15000.0 nM 4.82
CHEMBL99369 PIRIDRONIC ACID IC50 = 20000.0 nM 4.70
CHEMBL870 ALENDRONIC ACID IC50 = 32000.0 nM 4.50
CHEMBL317573 IC50 = 36000.0 nM 4.44
CHEMBL98810 IC50 = 38000.0 nM 4.42
CHEMBL98719 IC50 = 40000.0 nM 4.40
CHEMBL100041 IC50 = 44000.0 nM 4.36
CHEMBL317313 IC50 = 1200000.0 nM -
CHEMBL834 PAMIDRONIC ACID IC50 = 167000.0 nM -
CHEMBL871 ETIDRONIC ACID IC50 = 380000.0 nM -
CHEMBL293522 IC50 = 310000.0 nM -
CHEMBL327763 IC50 = 150000.0 nM -