Assay Detail
Binding
CHEMBL664705
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Evaluated for the inhibition of dihydrofolate reductase in Lactobacillus casei
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Lacticaseibacillus casei |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Folate analogues. 30. Synthesis and biological evaluation of N10-propargyl-5,8-dideaza-5,6,7,8-tetrahydrofolic acid and related compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.91 | 5.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL422395 | — | — | 1 | 5.31 |
| CHEMBL22793 | — | — | 1 | 5.00 |
| CHEMBL22708 | — | — | 1 | 4.80 |
| CHEMBL279508 | — | — | 1 | 4.52 |
| CHEMBL22449 | — | — | 1 | - |
| CHEMBL22290 | — | — | 1 | - |
| CHEMBL441958 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL422395 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL22793 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL22708 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL279508 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL22449 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL22290 | — | IC50 | = | 190000.0 | nM | - |
| CHEMBL441958 | — | IC50 | > | 200000.0 | nM | - |