Assay Detail
Binding
CHEMBL664709
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Inhibitory activity against Dihydrofolate reductase from Lactobacillus casei (lcDHFR)
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Lacticaseibacillus casei |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Structure-based design and synthesis of lipophilic 2,4-diamino-6-substituted quinazolines and their evaluation as inhibitors of dihydrofolate reductases and potential antitumor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.09 | 7.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL114354 | — | — | 1 | 7.68 |
| CHEMBL22 | TRIMETHOPRIM | 4.0 | 1 | 7.27 |
| CHEMBL117750 | — | — | 1 | 7.23 |
| CHEMBL115804 | — | — | 1 | 6.92 |
| CHEMBL119 | TRIMETREXATE | 4.0 | 1 | 6.58 |
| CHEMBL114833 | — | — | 1 | 5.80 |
| CHEMBL114839 | — | — | 1 | 5.75 |
| CHEMBL116637 | — | — | 1 | 5.70 |
| CHEMBL116200 | — | — | 1 | 5.68 |
| CHEMBL116815 | — | — | 1 | 5.64 |
| CHEMBL115474 | — | — | 1 | 5.57 |
| CHEMBL113999 | — | — | 1 | 5.55 |
| CHEMBL116816 | — | — | 1 | 5.52 |
| CHEMBL114058 | — | — | 1 | 4.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL114354 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL22 | TRIMETHOPRIM | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL117750 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL115804 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL119 | TRIMETREXATE | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL114833 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL114839 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL116637 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL116200 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL116815 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL115474 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL113999 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL116816 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL114058 | — | IC50 | = | 37000.0 | nM | 4.43 |