Assay Detail
Binding
CHEMBL664714
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Inhibitory concentration against Lactobacillus casei Dihydrofolate reductase
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Lacticaseibacillus casei |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Effect of C9-methyl substitution and C8-C9 conformational restriction on antifolate and antitumor activity of classical 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.14 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 7.96 |
| CHEMBL323565 | — | — | 1 | 7.00 |
| CHEMBL104829 | FURO[2,3D]PYRIMIDINE ANTIFOLATE | — | 1 | 6.66 |
| CHEMBL106628 | — | — | 1 | 6.25 |
| CHEMBL430872 | — | — | 1 | 5.68 |
| CHEMBL1237205 | — | — | 1 | 5.36 |
| CHEMBL2092925 | — | — | 1 | 4.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL34259 | METHOTREXATE | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL323565 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL104829 | FURO[2,3D]PYRIMIDINE ANTIFOLATE | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL106628 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL430872 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL1237205 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL2092925 | — | IC50 | = | 84000.0 | nM | 4.08 |