Assay Detail
Binding
CHEMBL664815
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of lanosterol 14 alpha-demethylase cytochrome P450 51A
4
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Lanosterol 14-alpha demethylase (CHEMBL4981) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Stereoisomers of ketoconazole: preparation and biological activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.48 | 7.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL157101 | KETOCONAZOLE | 4.0 | 2 | 7.33 |
| CHEMBL328863 | — | — | 1 | 5.86 |
| CHEMBL319160 | — | — | 1 | 5.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL157101 | KETOCONAZOLE | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL157101 | KETOCONAZOLE | IC50 | = | 119.0 | nM | 6.92 |
| CHEMBL328863 | — | IC50 | = | 1370.0 | nM | 5.86 |
| CHEMBL319160 | — | IC50 | = | 1600.0 | nM | 5.80 |