Assay Detail
Binding
CHEMBL664863
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition constant for Phe31-dihydrofolate reductase (DHFR)-NADPH-Compound complex
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Evaluation of the importance of hydrophobic interactions in drug binding to dihydrofolate reductase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 1 | 7.36 | 7.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL29143 | — | — | 1 | 7.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL29143 | — | Ki | = | 44.0 | nM | 7.36 |