Assay Detail
Binding
CHEMBL664866
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Inhibition constant against Dihydrofolate reductase
11
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
High throughput screening identifies novel inhibitors of Escherichia coli dihydrofolate reductase that are competitive with dihydrofolate.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 6.70 | 8.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL22 | TRIMETHOPRIM | 4.0 | 1 | 8.42 |
| CHEMBL1160541 | — | — | 1 | 7.58 |
| CHEMBL82334 | — | — | 1 | 7.39 |
| CHEMBL310759 | — | — | 2 | 7.21 |
| CHEMBL85364 | — | — | 1 | 7.19 |
| CHEMBL84108 | — | — | 1 | 6.89 |
| CHEMBL82825 | — | — | 1 | 6.72 |
| CHEMBL309713 | — | — | 1 | 5.70 |
| CHEMBL80014 | — | — | 1 | 4.96 |
| CHEMBL82985 | — | — | 1 | 4.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL22 | TRIMETHOPRIM | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL1160541 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL82334 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL310759 | — | Ki | = | 61.0 | nM | 7.21 |
| CHEMBL85364 | — | Ki | = | 65.0 | nM | 7.19 |
| CHEMBL310759 | — | Ki | = | 93.0 | nM | 7.03 |
| CHEMBL84108 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL82825 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL309713 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL80014 | — | Ki | = | 11000.0 | nM | 4.96 |
| CHEMBL82985 | — | Ki | = | 23000.0 | nM | 4.64 |