Assay Detail
Binding
CHEMBL664885
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Inhibitory activity against Escherichia coli dihydrofolate reductase
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
On the optimization of hydrophobic and hydrophilic substituent interactions of 2,4-diamino-5-(substituted-benzyl)pyrimidines with dihydrofolate reductase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 7.19 | 8.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL57343 | — | — | 1 | 8.02 |
| CHEMBL57383 | — | — | 1 | 7.94 |
| CHEMBL300114 | — | — | 1 | 7.80 |
| CHEMBL280378 | EPIROPRIM | 2.0 | 1 | 7.66 |
| CHEMBL21395 | — | — | 1 | 7.35 |
| CHEMBL56129 | — | — | 1 | 7.13 |
| CHEMBL434787 | — | — | 1 | 6.92 |
| CHEMBL56146 | — | — | 1 | 6.89 |
| CHEMBL298955 | — | — | 1 | 6.60 |
| CHEMBL31055 | — | — | 1 | 6.57 |
| CHEMBL19414 | — | — | 1 | 6.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL57343 | — | Ki | = | 9.55 | nM | 8.02 |
| CHEMBL57383 | — | Ki | = | 11.48 | nM | 7.94 |
| CHEMBL300114 | — | Ki | = | 15.85 | nM | 7.80 |
| CHEMBL280378 | EPIROPRIM | Ki | = | 21.88 | nM | 7.66 |
| CHEMBL21395 | — | Ki | = | 44.67 | nM | 7.35 |
| CHEMBL56129 | — | Ki | = | 74.13 | nM | 7.13 |
| CHEMBL434787 | — | Ki | = | 120.23 | nM | 6.92 |
| CHEMBL56146 | — | Ki | = | 128.82 | nM | 6.89 |
| CHEMBL298955 | — | Ki | = | 251.19 | nM | 6.60 |
| CHEMBL31055 | — | Ki | = | 269.15 | nM | 6.57 |
| CHEMBL19414 | — | Ki | = | 630.96 | nM | 6.20 |