Assay Detail
Binding
CHEMBL664986
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested in vitro for its ability to displace [125 I]Tyr-sauvagine from corticotropin-releasing hormone type 1 receptor in rat cerebellum
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Cerebellum |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Corticotropin-releasing factor receptor 1 (CHEMBL4649) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and biological activity of fluoro-substituted pyrrolo[2,3-d]pyrimidines: the development of potential positron emission tomography imaging agents for the corticotropin-releasing hormone type 1 receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 8.38 | 9.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL434882 | — | — | 1 | 9.04 |
| CHEMBL164206 | — | — | 1 | 8.64 |
| CHEMBL296641 | ANTALARMIN | — | 1 | 8.60 |
| CHEMBL348967 | — | — | 1 | 8.46 |
| CHEMBL163618 | — | — | 1 | 8.00 |
| CHEMBL164042 | — | — | 1 | 7.52 |
| CHEMBL159575 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL434882 | — | Ki | = | 0.91 | nM | 9.04 |
| CHEMBL164206 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL296641 | ANTALARMIN | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL348967 | — | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL163618 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL164042 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL159575 | — | Ki | > | 1000.0 | nM | - |