Assay Detail
Functional
CHEMBL665162
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Concentration required to inhibit the growth of chang liver cells.
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Analogues of methotrexate in rheumatoid arthritis. 2. Effects of 5-deazaaminopterin, 5,10-dideazaaminopterin, and analogues on type II collagen-induced arthritis in mice.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 7.26 | 8.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL114733 | — | — | 1 | 8.20 |
| CHEMBL127004 | — | — | 1 | 8.09 |
| CHEMBL123980 | — | — | 1 | 7.96 |
| CHEMBL113799 | — | — | 1 | 7.92 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 7.85 |
| CHEMBL127287 | — | — | 1 | 7.85 |
| CHEMBL123527 | — | — | 1 | 7.52 |
| CHEMBL439604 | — | — | 1 | 7.47 |
| CHEMBL124631 | — | — | 1 | 7.43 |
| CHEMBL12094 | — | — | 1 | 7.11 |
| CHEMBL110251 | — | — | 1 | 7.11 |
| CHEMBL127834 | — | — | 1 | 7.05 |
| CHEMBL428862 | — | — | 1 | 6.91 |
| CHEMBL340673 | — | — | 1 | 6.90 |
| CHEMBL69016 | — | — | 1 | 6.48 |
| CHEMBL112061 | — | — | 1 | 6.23 |
| CHEMBL127943 | — | — | 1 | 5.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL114733 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL127004 | — | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL123980 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL113799 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL127287 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL123527 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL439604 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL124631 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL12094 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL110251 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL127834 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL428862 | — | IC50 | = | 123.0 | nM | 6.91 |
| CHEMBL340673 | — | IC50 | = | 126.0 | nM | 6.90 |
| CHEMBL69016 | — | IC50 | = | 334.0 | nM | 6.48 |
| CHEMBL112061 | — | IC50 | = | 593.0 | nM | 6.23 |
| CHEMBL127943 | — | IC50 | = | 4110.0 | nM | 5.39 |