Assay Detail
Binding
CHEMBL665204
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Inhibitory activity against Dihydrofolate reductase in rat liver
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Liver |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Quinazoline antifolate thymidylate synthase inhibitors: alkyl, substituted alkyl, and aryl substituents in the C2 position.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 6.39 | 7.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL389051 | — | — | 1 | 7.12 |
| CHEMBL103059 | — | — | 1 | 5.65 |
| CHEMBL434209 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL389051 | — | Ki | = | 75.0 | nM | 7.12 |
| CHEMBL103059 | — | Ki | = | 2250.0 | nM | 5.65 |
| CHEMBL434209 | — | Ki | > | 2660.0 | nM | - |