Assay Detail
Binding
CHEMBL665205
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Inhibitory activity of compound against rat liver Dihydrofolate reductase
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Nonclassical 2,4-diamino-5-aryl-6-ethylpyrimidine antifolates: activity as inhibitors of dihydrofolate reductase from Pneumocystis carinii and Toxoplasma gondii and as antitumor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 10.39 | 10.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL449706 | — | — | 1 | 10.85 |
| CHEMBL264373 | METOPRINE | -1.0 | 1 | 9.92 |
| CHEMBL102850 | — | — | 1 | - |
| CHEMBL102418 | — | — | 1 | - |
| CHEMBL56170 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL449706 | — | Ki | = | 0.014 | nM | 10.85 |
| CHEMBL264373 | METOPRINE | Ki | = | 0.12 | nM | 9.92 |
| CHEMBL102850 | — | Ki | = | 0.0004 | nM | - |
| CHEMBL102418 | — | Ki | = | 0.00035 | nM | - |
| CHEMBL56170 | — | Ki | = | 0.009 | nM | - |