Assay Detail
Binding
CHEMBL665213
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In vitro inhibition of rat liver dihydrofolate reductase.
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
2,4-Diamino-5-benzylpyrimidines as antibacterial agents. 13. Some alkenyl derivatives with high in vitro activity against anaerobic organisms.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 4.65 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL23746 | — | — | 1 | 5.70 |
| CHEMBL24503 | — | — | 1 | 5.70 |
| CHEMBL59470 | — | — | 1 | 5.02 |
| CHEMBL61357 | — | — | 1 | 4.96 |
| CHEMBL59416 | — | — | 1 | 4.83 |
| CHEMBL58550 | — | — | 1 | 4.82 |
| CHEMBL301236 | — | — | 1 | 4.75 |
| CHEMBL26337 | — | — | 1 | 4.68 |
| CHEMBL60821 | — | — | 1 | 4.62 |
| CHEMBL301030 | — | — | 1 | 4.57 |
| CHEMBL279455 | — | — | 1 | 4.50 |
| CHEMBL59369 | — | — | 1 | 4.46 |
| CHEMBL303075 | — | — | 1 | 4.44 |
| CHEMBL278345 | — | — | 1 | 4.43 |
| CHEMBL412892 | — | — | 1 | 4.31 |
| CHEMBL282022 | — | — | 1 | 4.30 |
| CHEMBL23338 | — | — | 1 | 4.24 |
| CHEMBL59952 | — | — | 1 | 4.03 |
| CHEMBL60069 | — | — | 1 | 4.03 |
| CHEMBL23609 | — | — | 1 | - |
| CHEMBL57878 | — | — | 1 | - |
| CHEMBL59946 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL23746 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL24503 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL59470 | — | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL61357 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL59416 | — | IC50 | = | 14700.0 | nM | 4.83 |
| CHEMBL58550 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL301236 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL26337 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL60821 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL301030 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL279455 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL59369 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL303075 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL278345 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL412892 | — | IC50 | = | 49000.0 | nM | 4.31 |
| CHEMBL282022 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL23338 | — | IC50 | = | 57000.0 | nM | 4.24 |
| CHEMBL59952 | — | IC50 | = | 94500.0 | nM | 4.03 |
| CHEMBL60069 | — | IC50 | = | 94500.0 | nM | 4.03 |
| CHEMBL23609 | — | IC50 | = | 140000.0 | nM | - |
| CHEMBL57878 | — | IC50 | = | 320000.0 | nM | - |
| CHEMBL59946 | — | IC50 | = | 150000.0 | nM | - |