Assay Detail
Binding
CHEMBL665288
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Cyclin E-cyclin-dependent kinase 2
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 2/cyclin E (CHEMBL2094126) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Structural classification of protein kinases using 3D molecular interaction field analysis of their ligand binding sites: target family landscapes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.71 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL23254 | PURVALANOL B | — | 1 | 8.05 |
| CHEMBL23327 | PURVALANOLA | — | 1 | 7.46 |
| CHEMBL14762 | SELICICLIB | 2.0 | 1 | 6.16 |
| CHEMBL280074 | OLOMOUCINE | — | 1 | 5.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL23254 | PURVALANOL B | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL23327 | PURVALANOLA | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL14762 | SELICICLIB | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL280074 | OLOMOUCINE | IC50 | = | 7000.0 | nM | 5.16 |