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Assay Detail

CHEMBL665303

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Compound was tested for the inhibitory constant for mouse kidney cytidine deaminase
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Cytidine deaminase (CHEMBL2110)
Type SINGLE PROTEIN
Organism Mus musculus

Publication

Synthesis of pyrimidin-2-one nucleosides as acid-stable inhibitors of cytidine deaminase.
Kim CH, Marquez VE, Mao DT, Haines DR, McCormack JJ.
J Med Chem (1986) 29 : 1374 -1380
PubMed 3735306 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 11 5.91 10.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL604436 1 10.00
CHEMBL2311129 1 7.00
CHEMBL605877 1 6.40
CHEMBL2311128 TETRAHYDROURIDINE 2.0 1 6.40
CHEMBL504567 ZEBULARINE 1 5.70
CHEMBL604220 1 5.40
CHEMBL1232227 1 5.40
CHEMBL1399702 NEBULARINE 1 5.00
CHEMBL3218780 1 5.00
CHEMBL604221 1 4.70
CHEMBL605678 1 4.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL604436 Ki = 0.1 nM 10.00
CHEMBL2311129 Ki = 100.0 nM 7.00
CHEMBL605877 Ki = 400.0 nM 6.40
CHEMBL2311128 TETRAHYDROURIDINE Ki = 400.0 nM 6.40
CHEMBL504567 ZEBULARINE Ki = 2000.0 nM 5.70
CHEMBL604220 Ki = 4000.0 nM 5.40
CHEMBL1232227 Ki = 4000.0 nM 5.40
CHEMBL1399702 NEBULARINE Ki = 10000.0 nM 5.00
CHEMBL3218780 Ki = 10000.0 nM 5.00
CHEMBL604221 Ki = 20000.0 nM 4.70
CHEMBL605678 Ki = 100000.0 nM 4.00