Assay Detail
Binding
CHEMBL665353
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Inhibitory concentration against Lactobacillus casei
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Lacticaseibacillus casei |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Synthesis of 5-methyl-5-deaza nonclassical antifolates as inhibitors of dihydrofolate reductases and as potential antipneumocystis, antitoxoplasma, and antitumor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.51 | 7.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL82924 | — | — | 1 | 7.44 |
| CHEMBL81820 | — | — | 1 | 6.07 |
| CHEMBL82975 | — | — | 1 | 6.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL82924 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL81820 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL82975 | — | IC50 | = | 960.0 | nM | 6.02 |