Assay Detail
Binding
CHEMBL665374
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Binding affinity was measured at cloned mammalian dopamine D2 receptor expressed in CHO-K1 cells (using [3H]U-86170)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO-K1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological activity of C-5 modified derivatives of (+)-AJ76 and (+)-UH232: Increased dopamine D3 receptor preference and improved pharmacokinetic properties
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.43 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL278751 | — | — | 1 | 7.82 |
| CHEMBL27441 | — | — | 1 | 6.84 |
| CHEMBL161811 | — | — | 1 | 6.26 |
| CHEMBL161507 | — | — | 1 | 5.63 |
| CHEMBL349843 | — | — | 1 | 5.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL278751 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL27441 | — | Ki | = | 145.0 | nM | 6.84 |
| CHEMBL161811 | — | Ki | = | 546.0 | nM | 6.26 |
| CHEMBL161507 | — | Ki | = | 2328.0 | nM | 5.63 |
| CHEMBL349843 | — | Ki | = | 2557.0 | nM | 5.59 |