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Compound Detail

CHEMBL161507

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CCCN[C@@H]1CCc2c(C(=O)OC)cccc2[C@@H]1C

Basic Information

ChEMBL ID CHEMBL161507
Phase Preclinical
Structure Type MOL
InChI Key IKYFNUXRYHSJTJ-XHDPSFHLSA-N
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

261.4
MW (Da)
2.89
ALogP
3
HBA
1
HBD
38.3
PSA (Ų)
0.85
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C16H23NO2
MW 261.37
Aromatic Rings 1
Heavy Atoms 19
NP-Likeness 0.21

Activity Summary

Ki 4 meas. best 6.6

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
D(3) dopamine receptor
CHEMBL234
Ki 6.6 6.6 253.0 1
5-hydroxytryptamine receptor 5A
CHEMBL3426
Ki 6.54 6.54 287.0 1
D(4) dopamine receptor
CHEMBL219
Ki 5.8 5.8 1593.0 1
D(2) dopamine receptor
CHEMBL217
Ki 5.63 5.63 2328.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
- 10.1016/S0960-894X(01)80181-5 Rattus norvegicus 4
- 10.1016/S0960-894X(01)80181-5 5-hydroxytryptamine receptor 5A 1
- 10.1016/S0960-894X(01)80181-5 D(2) dopamine receptor 1
- 10.1016/S0960-894X(01)80181-5 D(3) dopamine receptor 1
- 10.1016/S0960-894X(01)80181-5 D(4) dopamine receptor 1

Data from ChEMBL 36 via Core Engine