Assay Detail
Binding
CHEMBL665453
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Inhibitory concentration against dihydrofolate reductase of rat liver
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
New 2,4-diamino-5-(2',5'-substituted benzyl)pyrimidines as potential drugs against opportunistic infections of AIDS and other immune disorders. Synthesis and species-dependent antifolate activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.33 | 8.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7492 | PIRITREXIM | 2.0 | 1 | 8.48 |
| CHEMBL35020 | — | — | 1 | 6.19 |
| CHEMBL284839 | — | — | 1 | 5.40 |
| CHEMBL288350 | — | — | 1 | 5.34 |
| CHEMBL35437 | — | — | 1 | 5.21 |
| CHEMBL34641 | — | — | 1 | 5.19 |
| CHEMBL34293 | — | — | 1 | 5.09 |
| CHEMBL38158 | — | — | 1 | 4.89 |
| CHEMBL35080 | — | — | 1 | 4.85 |
| CHEMBL288647 | — | — | 1 | 4.72 |
| CHEMBL290806 | — | — | 1 | 4.68 |
| CHEMBL289908 | — | — | 1 | 4.60 |
| CHEMBL34378 | — | — | 1 | 4.60 |
| CHEMBL22 | TRIMETHOPRIM | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7492 | PIRITREXIM | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL35020 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL284839 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL288350 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL35437 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL34641 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL34293 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL38158 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL35080 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL288647 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL290806 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL289908 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL34378 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL22 | TRIMETHOPRIM | IC50 | = | 180000.0 | nM | - |