Assay Detail
Functional
CHEMBL665579
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ability to inhibit conversion of [3H]L-Arg to [3H]L-citrulline catalyzed by inducible NOS (i NOS) from human DLD-1 cells
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | DLD-1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
3,4-Dihydro-1-isoquinolinamines: a novel class of nitric oxide synthase inhibitors with a range of isoform selectivity and potency.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.47 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7889 | L-NIL | — | 1 | 6.89 |
| CHEMBL256147 | TILARGININE | 3.0 | 1 | 6.52 |
| CHEMBL414608 | — | — | 1 | 6.26 |
| CHEMBL266226 | — | — | 1 | 5.92 |
| CHEMBL7931 | — | — | 1 | 5.89 |
| CHEMBL8065 | — | — | 1 | 5.57 |
| CHEMBL8272 | — | — | 1 | 5.57 |
| CHEMBL274402 | — | — | 1 | 5.38 |
| CHEMBL225304 | PIMAGEDINE | 2.0 | 1 | 5.35 |
| CHEMBL7969 | — | — | 1 | 5.33 |
| CHEMBL8088 | — | — | 1 | 5.26 |
| CHEMBL7946 | — | — | 1 | 5.05 |
| CHEMBL7890 | L-NAME | 2.0 | 1 | 4.85 |
| CHEMBL8390 | — | — | 1 | 4.75 |
| CHEMBL7891 | — | — | 1 | 4.50 |
| CHEMBL268403 | — | — | 1 | 4.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7889 | L-NIL | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL256147 | TILARGININE | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL414608 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL266226 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL7931 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL8065 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL8272 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL274402 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL225304 | PIMAGEDINE | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL7969 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL8088 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL7946 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL7890 | L-NAME | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL8390 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL7891 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL268403 | — | IC50 | = | 33000.0 | nM | 4.48 |