Assay Detail
Binding
CHEMBL665618
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Inhibition of dihydrofolate reductase in Toxoplasma gondii.
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
2,4-Diaminothieno[2,3-d]pyrimidine analogues of trimetrexate and piritrexim as potential inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.07 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL119 | TRIMETREXATE | 4.0 | 1 | 8.00 |
| CHEMBL7492 | PIRITREXIM | 2.0 | 1 | 7.96 |
| CHEMBL104787 | — | — | 1 | 7.16 |
| CHEMBL323960 | — | — | 1 | 6.89 |
| CHEMBL326200 | — | — | 1 | 6.50 |
| CHEMBL322315 | — | — | 1 | 6.20 |
| CHEMBL325333 | — | — | 1 | 6.07 |
| CHEMBL323155 | — | — | 1 | 5.55 |
| CHEMBL322585 | — | — | 1 | 5.48 |
| CHEMBL104555 | — | — | 1 | 5.41 |
| CHEMBL107023 | — | — | 1 | 5.24 |
| CHEMBL320811 | — | — | 1 | 5.19 |
| CHEMBL322861 | — | — | 1 | 4.75 |
| CHEMBL104379 | — | — | 1 | 4.62 |
| CHEMBL107167 | — | — | 1 | - |
| CHEMBL321826 | — | — | 1 | - |
| CHEMBL107079 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL119 | TRIMETREXATE | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL7492 | PIRITREXIM | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL104787 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL323960 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL326200 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL322315 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL325333 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL323155 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL322585 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL104555 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL107023 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL320811 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL322861 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL104379 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL107167 | — | IC50 | > | 28000.0 | nM | - |
| CHEMBL321826 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL107079 | — | IC50 | > | 70000.0 | nM | - |