Assay Detail
Binding
CHEMBL665734
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]0-CRF from human Corticotropin releasing factor receptor 1 expressed in CHO cells
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Corticotropin-releasing factor receptor 1 (CHEMBL1800) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Pyrazolo[1,5-a]pyrimidine CRF-1 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 7.40 | 8.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL65078 | — | — | 1 | 8.49 |
| CHEMBL290762 | — | — | 1 | 8.30 |
| CHEMBL305092 | — | — | 1 | 8.19 |
| CHEMBL302645 | — | — | 1 | 7.96 |
| CHEMBL292764 | — | — | 1 | 7.82 |
| CHEMBL303789 | — | — | 1 | 7.40 |
| CHEMBL303593 | — | — | 1 | 7.39 |
| CHEMBL9946 | CP-154526 | — | 1 | 7.25 |
| CHEMBL292484 | — | — | 1 | 7.16 |
| CHEMBL62533 | — | — | 1 | 7.11 |
| CHEMBL65724 | — | — | 1 | 7.03 |
| CHEMBL65574 | — | — | 1 | 6.67 |
| CHEMBL65308 | — | — | 1 | 6.51 |
| CHEMBL65195 | — | — | 1 | 6.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL65078 | — | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL290762 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL305092 | — | Ki | = | 6.4 | nM | 8.19 |
| CHEMBL302645 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL292764 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL303789 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL303593 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL9946 | CP-154526 | Ki | = | 56.0 | nM | 7.25 |
| CHEMBL292484 | — | Ki | = | 69.0 | nM | 7.16 |
| CHEMBL62533 | — | Ki | = | 77.0 | nM | 7.11 |
| CHEMBL65724 | — | Ki | = | 93.0 | nM | 7.03 |
| CHEMBL65574 | — | Ki | = | 216.0 | nM | 6.67 |
| CHEMBL65308 | — | Ki | = | 310.0 | nM | 6.51 |
| CHEMBL65195 | — | Ki | = | 511.0 | nM | 6.29 |